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In a subsequent clinical study conducted at VCU, the researchers also observed that experienced e-cigarette users were more likely to take longer puffs than novice users, resulting in higher levels of nicotine being delivered to their bloodstream. According to Eissenberg, these findings indicate that without federal regulation on these devices users could become more addicted to nicotine from e-cigarette use than from smoking a conventional combustible cigarette. When used as intended, an electronic cigarette should not produce a nicotine yield in excess of that of a combustible cigarette, a device that we already know has lethal health effects. If it does, then we are essentially making an already addictive drug delivery system even more addictive, said Eissenberg. Tobacco use remains the leading cause of preventable cancer incidence in the U.S., with the general assumption that e-cigarettes are a safer alternative as a nicotine delivery method. This could be true, Eissenberg stated, as long as the e-cigarette device and its liquid are not designed in a way that would deliver excessive levels of the addictive substance or other dangerous chemicals to the user. However, restrictions dictating safer design may only occur through federal regulation since product developers may not be inclined to self-impose such regulations. With this novel nicotine mathematical model, researchers will now be able to predict with a great deal of accuracy how much nicotine will be delivered to an e-cigarette user before a device is even designed. These predictions will further enable researchers like Eissenberg and his colleagues to inform federal regulators about evidence-based recommendations on e-cigarette design restrictions that could potentially avoid a serious public health disaster as more people turn to e-cigarettes as an alternative nicotine delivery method. This model also sets the framework for a clinical trial that has just opened at the VCU CSTP as well as Penn State Universitys Tobacco Center of Regulatory Science in Hershey, Pa., that will evaluate novel tobacco products, including e-cigarettes, on health indicators and cigarette smoking behavior in people who are currently smoking tobacco cigarettes and who are interested in reducing their cigarette use. Eissenberg collaborated to develop the aerosol nicotine exposure model with lead author Alan Shihadeh, Sc.D.
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